One of the hidden gems in PowerGUI Script Editor is the ability to fully customize its toolbars and hotkeys.
Say, you want to have a hotkey to collapse all regions in a PowerShell script – this could not be easier, just:
- On the Tools menu, click Customize.
- In the Customize dialog box, click the Keyboard tab.
- On the Keyboard tab, select the command you need.
- In the Press shortcut key(s), assign the hotkey you want.
Other tabs of this dialog box are also useful:
- Toolbars – lets you create your own toolbars.
- Commands – lets you add buttons to existing toolbars by simply dragging them from the dialog box to the toolbar.
Hope this makes your PowerShell scripting even more enjoyable!
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Dmitry's Blog: Cloud, PowerShell and beyond 
I like to remove a hotkey because I cannot type the pipe character on Hungarian keyboard. After a PowerGUI restarted the hotkey is there again!
Hoe can I disable It permanently???
Tibor,
I am no longer on the PowerGUI team and it has been awhile… If I remember right, there was a configuration file that contained the info which you could delete or rename to reset the shortcuts… You can actually delete or rename the whole configuration folder if you do not care about your customizations, etc.
If this does not help – ask on the forums at powergui.org.
Dmitry